01% The mean percentage recoveries ranged from 99 82 �� 0 10, in

01%. The mean percentage recoveries ranged from 99.82 �� 0.10, indicating selleckchem Bosutinib the accuracy of the proposed method. These values are very close to 100, indicating the accuracy of the proposed method. Low values of standard deviation, coefficient of variation, and standard error further validated the method. Thus, it may be concluded that the proposed method of analysis is new, cost-effective, environment-friendly, safe, accurate, and reproducible. This method can be successfully applied in routine analysis of cefpodoxime proxetil tablet formulation. The equation of the calibration curve for cefpodoxime proxetil obtained was y = 0.010x + 0.010; the calibration curve was found to be linear in the aforementioned concentrations (the correlation coefficient (r2) of determination was 0.

996) [Figures [Figures22 and and33]. Figure 2 UV spectra of cefpodoxime proxetil standard and test tablet from 400 – 200 nm Figure 3 Calibration curve of cefpodoxime proxetil CONCLUSION Developed spectrophotometric cefpodoxime proxetil by using different hydrotropic agents was found to be the best alternative for estimations of poorly water-soluble drugs and to minimize the use of organic solvents. The proposed method utilizes solution of non-toxic, non-volatile hydrotropic agents, which give a novel, economical, and environment-friendly method for the estimation of cefpodoxime proxetil in tablet dosage forms. Footnotes Source of Support: Nil Conflict of Interest: None declared.
Type 2 diabetes is a long-term metabolic disorder wherein the body becomes resistant to the effects of insulin, a hormone that regulates sugar absorption.

Treatment of type-2 diabetes (noninsulin-dependent) is now possible with orally administered hypoglycemic agents that help to reduce blood sugar levels.[1] Repaglinide is a carbomoxylmethyl benzoic acid derivative, also known as 2-ethoxy-4-[2-[[3-methyl-1-[2-Cl-piperidinyl)phenyl]butyl]amino]-2-oxyethyl]. The chemical structure of repaglinide is shown in Figure 1. Repaglinide is a meglitinide antidiabetic drug used for the treatment of type-2 diabetes mellitus and it lowers blood glucose by stimulating the release of insulin from the pancreas. It achieves this by closing ATP-dependent potassium channels in the membrane of the ��-cells.[2,3] Figure 1 Repaglinide Technology and scientific progress has led to the development of numerous synthetic drugs.

The increase utilization of these antidiabetic drugs demands the development of new and alternative methods to successfully determine these drugs in raw material, pharmaceutical dosage form and in the biological fluids. Extensive literature survey reveals that previous studies have reported the determination of repaglinide employing UV and visible spectrophotomeric,[4�C6] spectrofluorimetric methods,[7] HPLC,[8,9] LCMS/MS focusing mainly Anacetrapib in its quantitation in plasma.

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