It is warranted to elucidate the mechanism of protective effect i

It is warranted to elucidate the mechanism of protective effect in patients with NAFLD. Figure 1. Time-to-BCR according to the presence of NAFLD. Disclosures: The

following people have nothing to disclose: Won-Mook Choi, Jeong-Hoon Lee, Young Ju Lee, Young Youn Cho, Yuri Cho, Dong Hyeon Lee, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon, Cheol Kwak, Hyo-Suk Lee (Introduction) Useful biomarkers for diagnosing nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are anticipated. In order to discover novel biomarkers, especially for activity and steatosis in NAFLD, we performed metabolomic screening. (Patients) This study included 105 NAFLD patients and 48 healthy controls. Using capillary electrophoresis and liquid chromatography with mass spectrometry, we analyzed low molecular-weight metabolites. Both activityrelated and steatosis-related metabolites were detected. Predictive calculation systems of activity Deforolimus mw and steatosis were established, and area under the curve (AUC), sensitivity and specificity Talazoparib chemical structure for diagnosis were investigated. (Results) 1. Twelve significant metabolites for activity were

detected. Five were amino acids or amino acid-related molecules, 1 bile acid, and 1 nitric oxide-related molecule, as well as others. Pro is the best metabolite for activity detection (5.84 in mild activity vs 6.85 in moderate-severe activity, p=0.006). Predictive calculation system for moderate-severe activity was established with 7 metabolites. AUC was 0.66, sensitivity 70% and specificity 64%.2. Sixteen significant metabolites for steatosis 上海皓元医药股份有限公司 were detected. Ten were amino acids or amino acid-related molecules, 2 bile acids, and 1 fatty acid-related molecule, as well as others. Gly is the best metabolite for steatosis detection (2.66 in mild steatosis vs 2.23 in moderate-severe activity, p=0.0016). Predictive calculation system of moderate-severe steatosis was established with 15 metabolites. AUC was 0.81, sensitivity 79% and specificity 77%. (Conclusion) Several metabolic products were found as biomarkers of activity and steatosis in NAFLD, and they could also be useful

for diagnosis of these conditions. The diagnostic ability of these metabolites and the predictive calculation system will be confirmed by validation study. Disclosures: The following people have nothing to disclose: Katsutoshi Tokushige, Etsuko Hashimoto, Kazuhisa Kodama, Maki Tobari, Noriko Matsushita, Tomomi Kogiso, Makiko Taniai, Nobuyuki Torii, Keiko Shiratori BACKGROUND: Hepatitis C virus (HCV) has been strongly associated with fibromyalgia, but fibromyalgia in patients with non-alcoholic steatohepatitis (NASH) has not been previously assessed. METHODS: We prospectively recruited patients in an outpatient hepatology clinic with cirrhosis due NASH, alcohol, and HCV. Patients with known inflammatory conditions and cancers were excluded.

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