Key Word(s): 1. Ursodeoxycholic acid; 2. colorectal adenomas; 3. colorectal cancer; 4. systematical review; Presenting Author: CHAN SEO PARK Additional Authors: BYUNG IKBYUNG IK, KYEONG OKKYEONG OK, SI HYUNGSI HYUNG, SUNG BUMSUNG BUM Corresponding Author: BYUNG IKBYUNG IK Affiliations: Yeungnam Trametinib purchase University College of Medicine Objective: Rectal carcinoid tumors ≤1 cm in size can be treated by endoscopic resection. The aim of this study was to investigate the clinical feature and to clarify the treatment outcome

of a technique named endoscopic submucosal resection with a ligation device (ESMR-L) in a large number of rectal carcinoid tumors. Methods: Between March 2007 and February 2013, 66 cases of carcinoid tumors in colorecum were detected and 55 cases of carcinoids estimated at 10 mm or less in diameter. 59 cases were treated endoscopically. 7 cases were removed by endoscopic biopsy, 13 cases were removed by conventional endoscopic mucosal resection (EMR) and 39 cases were removed by endoscopic submucosal resection with a ligation device (ESMR-L). The clinical feature, selection of treatment, complete resection rate, local recurrence, distant metastases and complications associated with the procedure were analyzed. Results: Of

66 cases were 37 males and 29 females with a mean age of 50.70 ± 12.53 years. Tumor size ranged from 0.3 to 2 cm in diameter, with an average

size of 0.83 ± 0.41 cm. Carcinoids were located in rectum (62 cases), sigmoid 上海皓元 colon (3 cases) and cecum (1 case). Distribution of rectal carcinoids were located in the 6.63 ± 2.98 cm Daporinad in vivo from anal verge. 52 cases of rectal carcinoids were treated by EMR or ESMR-L. The mean lengths of hospital stay were 2.7 days. Complete resection of the lesions was obtained in 88.5% (46/52). The complete resection rates were 61.5% (8/13) by conventional EMR and 97.4% (38/39) by endoscopic submucosal resection with a ligation device. ESMR-L was superior to conventional EMR in terms of complete resection (p = 0.003). Minor bleeding associated with the ESMR-L occurred in two lesions (5.1%), but all cases were successfully managed with hemoclips. Histopathologically, all tumors were confined to submucosal layer. 2 cases were with lymphovascular invasion, 1 case was with perineural invasion and 7 cases were with remnant tumor cells at resection margin. But, neither local recurrence nor distant metastasis of all rectal carcinoids was detected during a median follow-up period of 49.6 ± 14.6 months. Conclusion: In our studies, ESMR-L proved to be a safe and effective procedure to resect rectal carcinoid tumors measuring less than 1 cm in a diameter. And ESMR-L is decidedly superior to conventional endoscopic polypectomy. Key Word(s): 1. Carcinoid tumor; 2. Rectum; 3.