Results: After climate changes, the mean prothrombin time decreased, while the fibrinogen, platelet, and Factor VIII levels rose. Conclusion: The results of this study suggest that the pollutants deployed in the Middle East can affect prothrombin time as well as fibrinogen, platelet, and Factor VII levels considerably and increase coagulant state. The pollutants can, consequently, increase the risk of Selleck BIBW2992 cardiovascular diseases. It seems that cooperation at government levels between Iran and its neighboring

countries is required to reverse desertification and avoid inaccurate usage of subterranean water resources so as to lessen air pollution. Key Words: Air pollution, Prothrombin Inhibitors,research,lifescience,medical time, Middle East Introduction Over the past two decades, a growing body of evidence has led to a heightened concern about the potential deleterious health effects of ambient air pollution

and its relation to cardiovascular diseases.1,2 Several air pollutants have been associated with increased hospitalization Inhibitors,research,lifescience,medical and mortality as a result of cardiovascular diseases and stroke.1-9 Based on the World Health Organization (WHO.) reports, annually more Inhibitors,research,lifescience,medical than 3,000,000 premature deaths occur all over the world, especially in under-developed countries, due to air pollution.10 Previously, many authors noted that exposure to air pollution can activate inflammatory pathways, produce reactive oxygen species, lead Inhibitors,research,lifescience,medical to endothelial injury and dysfunction and thus arterial vasoconstriction, and effect

alterations in blood coagulation factors. Thus far, the exact underlying mechanisms linking air pollutants to increased cardiovascular risk has remained unclear.2,11-13 Recently, the American Heart Association (AHA) published a statement on the importance of air pollution in the development of cardiovascular diseases. One of the potential biological mechanisms linking air pollution to cardiovascular diseases in the AHA statement involves indirect effects mediated through pulmonary Inhibitors,research,lifescience,medical inflammation and oxidative stress, which develop into a systemic inflammatory response.1 Several studies have shown that aside from respiratory disorders, allergies, and cancers, little articles (less than 10 PM) in the air can decrease coagulation time and consequently increase the risk of cardiovascular diseases. see more These studies have primarily focused on the effect of pollutants from gasoline, petroleum, coal, and other fossil energy sources; be that as it may, little attention has been paid to the consequences of dust and sand on coagulant factors.14 During the past two years, a substantial amount of dust and dirt originating from Iraqi and Saudi deserts and arid wastelands has blanketed large areas of the Middle East, not least in Iran.15 The dust is mostly composed of clay (.