0 for > 5%, hiatal hernia < 3 cm and esophagitis < LA Grade D. Bipolar stitch electrodes and an implantable pulse generator

(EndoStim BV, the Hague, Netherlands) was implanted using laparoscopy. EST at 20 Hz, 220 usec, 3–8 mAmp in 30 minutes, 6–12 sessions was delivered starting on day 1 post-implant. Patients are being evaluated using GERD-HRQL, symptom diaries and SF-12, and esophageal pH testing at regular intervals. Stimulation sessions are optimized based on residual symptoms, pH data when available and lead impedance at follow-up. Results: Twenty-five patients (mean age = 53; sd = 12 years; men = 14) were successfully implanted, 23 agreed to participate in the 2 year extension trial and 21 have completed their 2-year evaluation. At 2-year there was a significant improvement in their median learn more GERD-HRQL on LES-EST compared to both their on-PPI (9 vs. 0, p = 0.001) and off-PPI (23.5 vs 0, p < 0.001) median GERD-HRQL and their median 24-hour distal esophageal acid exposure (10.1 vs 4.7, p < 0.001). 71% patients reported either normalization or at least 50% reduction in their distal esophageal acid exposure.

All but two patient reported cessation of regular PPI use (> 50% of days with PPI use). There were no implantation- or stimulation-related unanticipated adverse events, or untoward sensation due to stimulation. There was no dysphagia and swallowing function assessed by manometry was also unaffected. selleck screening library Conclusion: LES-EST is safe and effective for treating patients with GERD over long-term 2 year duration. There was a significant and sustained improvement in symptoms, esophageal acid exposure and reduction in PPI use. Further, LES-EST is not associated with any GI side-effects or adverse events and can be optimized to individual patient needs. Key Word(s): 1. GERD; 2. reflux; 3. stimulation;

4. LES-EST; Presenting Author: ALEJANDRO PISCOYA Additional Authors: LUISFERNANDO NG-SUENG, IVAN VARGAS-MATOS, JOEL FLORES-ARRIAGA, SANTIAGO BELTRAN-FLORES, MAURICIO LEMA-CORREA, medchemexpress PERCY MAYTA-TRISTAN Corresponding Author: IVAN VARGAS-MATOS, ALEJANDRO PISCOYA Affiliations: Universidad Peruana de Ciencias Aplicadas; Universidad Peruana de Ciencias Aplicads Objective: Functional gastrointestinal diseases (FGID) are pathologies characterized by the absence of a definite organic etiology. Among them we find Irritable Bowel Syndrome (IBS) and Functional Dyspepsia (FD). Evidence describes patients with both diseases that are common and hard to differentiate. Having in consideration that literature describes FGID association with psychosocial factors such as stress, it is vital to study populations with high levels of those, such as medical students. Moreover, it is essential to clear out the relation between prevalent substance intake (tobacco and alcohol) in this population and FGID.