Accordingly, these two drugs could be safely administered together, and it is expected that they would demonstrate similar pharmacokinetic characteristics compared with the monotherapy of each drug. Acknowledgments This study was funded by LG Life Sciences Ltd (Seoul,
Republic of Korea), the manufacturer of gemigliptin. This study was supported by a grant from the Korean Health Technology R&D Smad inhibitor Project, Ministry of Health & Welfare, Republic of Korea (No. HI07C0001). Open AccessThis article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. References 1. Nyenwe EA, Jerkins TW, Umpierrez GE, Kitabchi AE. Management of type 2 diabetes: evolving strategies for the treatment of patients with type 2 diabetes. Metabolism. 2011;60:1–23. doi:10.1016/j.metabol.2010.09.010.PubMedCentralPubMedCrossRef 2. Intensive blood-glucose control with sulphonylureas or insulin PF477736 nmr compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998;352:837–53. pii: S0140673698070196. 3. Turner RC, Cull CA, Frighi V, Holman RR. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement
for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. JAMA. 1999;281:2005–12 pii: joc72221.PubMedCrossRef 4. Kramer W, Muller G, Geisen K. Characterization of the molecular mode of action of the sulfonylurea, glimepiride, at beta-cells. Horm Metab Res. 1996;28:464–8. doi:10.1055/s-2007-979838.PubMedCrossRef 5. Bell DS, Ovalle F. How long can insulin therapy be avoided in the patient with type 2 diabetes mellitus by use of a combination of metformin and a sulfonylurea? Endocr Pract. 2000;6:293–5 pii: ep99064.or.PubMedCrossRef 6. DeFronzo RA. Pharmacologic therapy for type 2 diabetes mellitus. Ann Intern Med. 1999;131:281–303 pii: 199908170-00008.PubMedCrossRef
7. Erle G, Lovise S, Stocchiero C, Lora L, Coppini A, Marchetti P, Merante D. A comparison of preconstituted, 3-mercaptopyruvate sulfurtransferase fixed combinations of low-dose glyburide plus metformin versus high-dose glyburide alone in the treatment of type 2 diabetic patients. Acta Diabetol. 1999;36:61–5 pii: 90360061.592.PubMedCrossRef 8. Tosi F, Muggeo M, Brun E, Spiazzi G, Perobelli L, Zanolin E, Gori M, Coppini A, Moghetti P. Combination treatment with metformin and glibenclamide versus single-drug therapies in type 2 diabetes mellitus: a randomized, double-blind, comparative study. Metabolism. 2003;52:862–7 pii: S002604950300101X.PubMedCrossRef 9. Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet. 2006;368:1696–705. doi:10.