6% in 1997 to 0.3% in 2003 after the implementation of a universal infant vaccination program

in 1990.15 Recent data in Hawaii show a reduction of 97% in the prevalence of HBsAg since the start of infant hepatitis B vaccination program in 1991. The incidence of acute HBV infections in children and adults was reduced from 4.5/100 000 in 1990 to zero in the period between 2002 and 2004 in Hawaii.16 In Taiwan, where universal vaccination of newborn was started in 1983–1985, the HBsAg prevalence in children younger than 15 years of age decreased from 9.8% in 1984 to 0.7% in 1999, Apoptosis Compound Library supplier and further to 0.5% in 2004.17 Mainland China is perhaps an excellent example where a lengthy process is required before the universal infant immunization program can be implemented. The Ministry of Health in China has recommended a 3-dose active HBV immunization to all infants since 1992, but families had to pay for such vaccination. In 2002, the Chinese

government fully integrated HBV vaccine into the routine immunization program (Expanded Programme on Immunization, EPI), in which free HBV vaccine was provided to all infants, but the families still had to pay for the service of the vaccination procedure. In 2005, the central government issued the “Regulation on Vaccine Circulation and Immunization Management”, which finally waived all vaccination-associated charges. Eventually, infants born after June 2005 were offered completely learn more free HBV vaccination. With the efforts of the government and free vaccination implemented, HBV vaccine coverage rate in children increased gradually from about 30% in 1992 to 90% in 2005.18 Because of the uneven economic development

across different regions, immunization coverage still remained relatively low in rural areas and in the western part of China. However, by the end of 2005, the coverage of HBV vaccination was believed to be 90%, 80%, and 70% in urban, rural and 上海皓元医药股份有限公司 remote areas, respectively. In 2006, a national survey of HBV seroepidemiology already showed a decrease in general prevalence of HBsAg from 9.75% in 1992 to 7.18% in 2006, and a decrease in the prevalence of HBsAg in children ≤ 5 years old from 9.67% in 1992 to 0.96% in 2006.19 Perinatally acquired chronic hepatitis B is traditionally classified into three phases.20 The immune tolerance phase marks the initial two to three decades when hepatitis B e antigen (HBeAg) is positive, HBV DNA is very high, alanine aminotransferase (ALT) is normal, and histologic injury is minimal. It is followed by the immune clearance phase when host immune clearance leads to a reduction in HBV DNA and elevation of ALT. Patients who have prolonged, unsuccessful immune clearance will have progressive liver fibrosis, which eventually develops into liver cirrhosis.