Anesthesia, surgical procedures,

and POCD Many authors have hypothesized that the changes in cognition may be due to anesthesia or surgical methods, especially, off- or on-pump procedure. There is currently no evidence that the type of anesthesia affects POCD outcome: In a study in 438 elderly patients aimed at evaluating the effects of anesthesia on cognitive dysfunction following surgery, no significant difference was found in the Inhibitors,research,lifescience,medical incidence of cognitive dysfunction 3 months after either general or regional anesthesia in elderly patients.23 Van Dijk and colleagues2 compared cognitive outcomes after off-pump and on-pump CABG over a 12-month period. The rates of cognitive decline were similar in the two groups at 3 months: 21% of the off-pump patients

and 29% of the on-pump Inhibitors,research,lifescience,medical patients. Rates of cognitive decline were similar at the the 12-month follow-up as well, suggesting that surgical Insult from on-pump surgery Is not the only contributing factor to cognitive deficiencies after CABG. Explaining discrepancies between studies of long-term POCD The extent to which postoperative cognitive dysfunction is detected will OSI-906 chemical structure depend on measurement Inhibitors,research,lifescience,medical techniques, timing of the assessment, and statistical methods, as well as on the characteristics of the patients selected for studies. One issue concerns the selection of neuropsychological tests.1 Because the cognitive changes may arise from more than one etiological mechanism, a procedure that assesses all major cognitive domains is recommended. If the test battery does not Include assessment of, for example, frontal-lobe functions such as planning and abstraction, Inhibitors,research,lifescience,medical or parietal-lobe functions

such as spatial and constructional abilities, abnormalities in these areas will be overlooked. Because of the limited time available for neurobehavioral testing preoperatively, few studies have included tests that cover Inhibitors,research,lifescience,medical all major cognitive domains. Second, criteria for what constitutes a cognitive Impairment have also varied between studies. Another Issue, relatively unexplored until now, is preoperative baseline performance.1,17 There is substantial variability in neuropsychological performance at baseline, with some patients Thymidine kinase performing at expected age-adjusted and education-adjusted levels and others performing significantly below expected levels. Some of the POCD cases are Interpreted as pre-existing dementia exacerbated by (or even detected for the first time after) anesthesia and surgery. A decline secondary to CABG in patients who are already impaired at baseline may be underestimated. European patient populations undergoing CABG are likely to be younger than their American counterparts and have fewer comorbld health problems.