As noted, the evidence for the effectiveness of ST over conventional therapy is still a matter of debate [37–39]. Lorlatinib purchase While Francavilla et al. [37] suggested

that 10-day ST achieved higher efficacy than conventional therapy (CT), Albrecht et al. [38] reported only boderline differences (relative risk, 1.26; 95% CI, 1.02–1.60) in ST compared with standard triple therapy. Prieto-Jimenez et al. [39] reported that a quadruple ST eradicated H. pylori in only half of the asymptomatic children in Texas. ST may, however, be much more effective in the eradication of clarithromycin-resistant strains (80 vs 0% [37]. The benefit of probiotics as therapeutic agents or adjunct to therapy against H. pylori is still a matter of debate, and recent studies have questioned the evidence for their beneficial effects [40,41]. Lionetti et al. [41] published a comprehensive review of preclinical and clinical studies on the role of probiotics in H. pylori infection focusing on pediatric literature between 1950 and 2009. They concluded that, while probiotics

represent a novel approach in the management of H. pylori infection, many of the studies LY2606368 ic50 to date do not have a sufficiently large sample size 上海皓元 to determine whether probiotics improve the eradication rates in conjunction with standard therapy. There is no evidence that probiotics alone should be used in the management of H. pylori infection. Data in children indicate that probiotics appear to be efficacious for the prevention of antibiotic-side effects such as diarrhea [41]. In addition, in vitro studies have demonstrated that the inhibitory activity of probiotics on H. pylori growth may be extremely strain specific. The meta-analysis of Szajewska et al.

[42] on the effects of Sacharomyces boulardii concluded that there is enough evidence to recommend the use of S. boulardii along with standard triple therapy as an option for increasing H. pylori eradication rates and decreasing the side effects of therapy particularly diarrhea. However, as the authors note, the number of studies is limited and all have methodological flaws particularly in relation to blinding and randomization. In addition, there is only one pediatric study with more than 50 children in each arm, and therefore, well-powered studies are still required to determine the effectiveness of probiotics in the management of H. pylori infection. Primary antibiotic resistance is a major factor of eradication failure in both adults and children.