Eight suggestive associations with P<1×10(-4) were carried through to in silico AZD7762 replication in 1292 AAA cases and 30503 controls. One single-nucleotide polymorphism associated with P<0.05 after Bonferroni correction in the in silico

study underwent further replication (706 AAA cases and 1063 controls from the United Kingdom, 507 AAA cases and 199 controls from Denmark, and 885 AAA cases and 1000 controls from New Zealand). Low-density lipoprotein receptor (LDLR) rs6511720 A was significantly associated overall and in 3 of 5 individual replication studies. The full study showed an association that reached genome-wide significance (odds ratio, 0.76; 95% confidence interval, 0.70-0.83; P=2.08×10(-10)).

Conclusions LDLR rs6511720 is associated with AAA. This finding is consistent with established

effects of this variant on coronary artery disease. Shared causal pathways with other cardiovascular diseases may present novel opportunities for preventative and therapeutic strategies for AAA.”
“Background: Iron deficiency (ID) can occur among exclusively breastfed infants before 6 mo of age.

Objective: The objective was to determine which subgroups of fully breastfed infants are at highest risk of ID.

Design: We assessed the prevalence of ID (ferritin < 12 mu g/L) and iron deficiency anemia (IDA; ferritin < 12 mu g/L and hemoglobin 105 g/L) and risk factors associated with ID and IDA at 6 mo among 404 fully breastfed VX-809 molecular weight infants with a birth weight >2500 g from 6 studies in Ghana, Honduras, Mexico, PD-1/PD-L1 Inhibitor 3 cell line and Sweden. Infants with an elevated C-reactive protein concentration (8%) were excluded.

Results: The percentages of infants with ID were 6% in Sweden, 17% in Mexico, 13-25% in Honduras, and 12-37% in Ghana. The percentages with IDA were 2% in Sweden, 4% in Mexico, 5-11% in Honduras, and 8-16% in Ghana. With data pooled, the key predictors of ID (20%) were male sex [adjusted odds ratio (AOR): 4.6; 95% CI: 2.5, 8.5] and birth weight 2500-2999 g (AOR: 2.4; 95% CI: 1.4, 4.3). The predictors of IDA (8%) were male sex (AOR: 7.6; 95% CI: 2.5, 23.0), birth weight of 2500-2999 g (AOR: 3.4; 1.5, 7.5), and weight gain above the

median since birth (AOR: 3.4; 95% CI: 1.3, 8.6). The combination of birth weight 2500-2999 g or male sex had a sensitivity of 91% for identifying ID and of 97% for identifying IDA.

Conclusions: Among fully breastfed infants with a birthweight. 2500 g, IDA is uncommon before 6 mo, but male infants and those with a birth weight of 2500-2999 g are at higher risk of ID and IDA. Am J Clin Nutr 2009;89:1433-40.”
“Dispersing conductive carbon black (CCB) particles into silicone rubber (SR), we studied the conductivity and piezoresistivity of particles filled polymer composite. The experimental results show that the conductive percolation threshold and shape exponent of composite are effected on by filler’s size and reduce with filler’s size decreasing.