However, presence of the C allele was significantly associated with the risk of development of hypertriglyceridemia.
Conclusion: Our data did not confirm the APOA5 -1131T>C variant as a risk factor for development of CAD in our sample of Iranians.”
“A simple, fast and cost effective method for determination of Aceclofenac in pure and tablet formulations has been developed check details and validated. The method is based on formation of stable blue coloured complex (lambda(max) = 740nm) of Aceclofenac with ammonium molybdate in presence of sulfuric acid under microwave irradiation for 5min. Peak shift in FT-IR spectra also indicated
the formation of complex. Measurement of absorbance was carried out at lambda(max) = 740nm. The reaction obeys Beer’s law over the concentration range of 50-250 mu g/ml of Aceclofenac. The RSD (intra-day and inter-day precision) for the drug is not greater than 0.95% and recoveries were found to be in range of 99.01-99.99%. The proposed method can be used successfully for routine analysis of Aceclofenac
in pure and tablet formulations.”
“Mitochondrial dysfunction is a major event involved in the pathogenesis of Huntington’s disease (HD). The present study evaluates the role of N-acetyl-L-cysteine (NAC) in preventing mitochondrial dysfunctions in a 3-nitropropionic acid (3-NP)-induced model of HD. Administration of 3-NP to rats (Wistar strain) resulted in significant inhibition of mitochondria! complexes II, IV and V in the striatum. However, no significant 5-Fluoracil in vitro effect on complex I was observed. Increased generation of reactive oxygen species and lipid peroxidation was observed in mitochondria of 3-NP-treated animals. Endogenous antioxidants (thiols and manganese-superoxide dismutase) were lowered in mitochondria of 3-NP-treated animals. 3-NP-treated animals showed increased cytosolic cytochrome c levels
and mitochondrial swelling. Increased expressions of caspase-3 and p53 were also observed in 3-NP-treated animals. Histopathological examination of the striata of 3-NP-treated animals revealed increased neural space, neurodegeneration and gliosis. This was accompanied by cognitive and motor deficits. NAC treatment, on the other hand, was found to be effective in reversing 3-NP-induced mitochondrial see more dysfunctions and neurobehavioral deficits. Our findings suggest a beneficial effect of NAC in HD. Copyright (C) 2012 S. Karger AG, Basel”
“Surgical options for pediatric patients with marked dysfunction of a single epileptogenic hemisphere have evolved over time. Complications resulting from highly resective operations such as anatomical hemispherectomy, including superficial siderosis and secondary hydrocephalus, have led to the development of less resective and more disconnective functional hemispherectomy. Functional hemispherectomy has recently given rise to hemispherotomy, the least resective operation primarily aimed at disconnecting the abnormal hemisphere.