Meckel the Elder’s grandson, Johann Friedrich Meckel the Younger (1781-1833), was a more prolific investigator and founder of the science of teratology. Many anatomic structures, such as Meckel’s diverticulum, bear his name, and he vastly expanded the university’s anatomic collection. August Albrecht Meckel (1789-1829), Meckel the Younger’s brother, practiced legal medicine

and investigated avian anatomy but died prematurely from tuberculosis. August’s son, Johann Heinrich Meckel (1821-1856), took the instructor’s position in pathologic anatomy at the University of Berlin that his great-grandfather had held at the Charite. After his untimely death from pulmonary disease, his position was filled by Rudolf Virchow. The history of this family is discussed

in detail.”
“OBJECTIVE: Patients with subarachnoid hemorrhage (SAH) are younger than typical stroke patients. Poor psychosocial outcome after SAH therefore leads MX69 molecular weight to a disproportionately high impact on patients, relatives, and society. Addressing this problem requires an understanding of what causes poor psychosocial outcome. Numerous studies have examined potential predictors but produced conflicting results. We aim to resolve this uncertainty about the potential value of individual predictors by conducting SP600125 a meta-analysis. This approach allows us to quantitatively combine the findings from all relevant studies to identify promising predictors of psychosocial outcome and determine the strength with which those predictors are associated with measures of psychosocial health.

METHODS: Psychosocial health was measured by health-related quality of life (HRQOL). We included in our analysis those predictors that were most frequently examined in this context, namely patient age, sex, neurologic state at the time of hospital admission, bleed severity, physical disability, cognitive impairment, and time between ictus and psychosocial assessment.

RESULTS: Only 1 of the traditional variables, physical disability, had any notable affect on HRQOL. Therefore,

the cause of most HRQOL impairment after SAH remains unknown. The situation is even worse for mental HRQOL, an area that is often significantly affected in SAH patients. Here, Ilomastat 90% of the variance remains unexplained by traditional predictors.

CONCLUSION: Studies need to turn to new factors to account for poor patient outcome.”
“OBJECTIVE: Exact intraoperative localization of pathologies in spinal and peripheral nerve surgery is not easily achieved. In spinal surgery, intraoperative fluoroscopy is the common method for identification of the level affected. It seldom visualizes the pathology itself and is prone to error in identifying anatomic disorders and superimposing structures. In peripheral nerve surgery, intraoperative fluoroscopy is of little value.