Moreover, each entry includes the list of infectious diseases caused by target see more organism with medical reference to related articles on Medscape eMedicine website (an online clinical medical knowledge base, http://emedicine.medscape.com), and the current state of research and applications of the particular enzybiotic. The range of available information is enhanced with numerous references to external resources and links to original papers for further reading. Table 1 Schema of the phiBIOTICS database entries Enzybiotics description Name Conventional
name of enzybiotic Recommended name Full name recommended by UniProt database (submitted or approved) Systematic name* Enzyme systematic name according to IUBMB Enzyme Nomenclature Alternative name Other name(s) in use UniProt ID Identifier JNJ-26481585 datasheet of corresponding entry in UniProt database General mode of action The overall mechanism of antimicrobial
action phiBIOTICS family Proposed enzybiotic family based upon enzymatic activity Reaction catalysed Biochemical reaction catalysed by the enzybiotic Source organism Name of the organism from which the enzybiotic was obtained Target organism Name of the organism(s) against which the enzybiotic is effective Disease List of diseases caused by target organisms State Current check details state of research and application(s) Reference Paper(s) describing enzybiotics properties
Relevant studies Antimicrobial agent Name of applied enzybiotic(s) and other agents eventually Study type in vitro or in vivo Model Organism(s) used as experimental model Administration* Applied route of administration of the enzybiotics Relevant results Significant outcomes of the research study Adverse effects and other issues* Manifested side effects (e.g. toxicity, immunogenicity, health issues) Reference Paper(s) related to the study * this item is not available for all entries. In the section of Relevant Studies, information about research Bcl-w studies concerning enzybiotics is presented. Each entry contains the name of tested enzybiotic (in some studies in combination with other antimicrobial agent, e.g. antibiotics); type of study (in vitro or in vivo); model (organism used in a specific study); route of administration (intravenous, intranasal, etc.); relevant results (summary of achieved results); adverse effects and other aspects (including toxicity, immunogenicity, emergence of resistance, health effects and further issues affecting enzymatic activity) and reference to related research papers.