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“OBJECTIVE: To estimate the effect of energy-based vessel sealing compared with suturing in women undergoing vaginal hysterectomy with respect to surgical outcomes.

DATA SOURCES: LBH589 concentration We searched the Cochrane Central Register of Controlled Trials, MEDLINE, and EMBASE.

We also screened references from relevant articles and searched trial registries and other sources of unpublished literature.

METHODS OF STUDY SELECTION: Randomized controlled trials comparing the use of energy-based vessel sealing devices with traditional suturing of vascular pedicles for vaginal hysterectomy, in women of any age, were included.

TABULATION, INTEGRATION, AND RESULTS: Two authors completed independent data extraction and bias assessment of included articles. We used the Grading of Recommendations Assessment, Development and AZD1208 datasheet Evaluation methodology to assess bias across studies at

the outcome level. Data were pooled based on the random effects model. Seven studies met inclusion criteria (n = 662). Energy-based vessel sealing devices decreased operative time by a mean of 17.2 minutes (seven studies, 662 patients; 95% confidence interval [CI] 7.5-27.0) blood loss by a mean of 47.7 mL (five studies, 437 patients; 95% CI 15.5-79.9), drop in hemoglobin by 0.3 g/dL (two studies, 291 patients; 95% CI 0.1-0.6), and postoperative hospital stay by 0.25 days (five studies, 554 patients; 95% CI 0.13-0.37). There was no increase in the rate of complications for energy-based vessel sealing compared with traditional suturing.

CONCLUSION: This review suggests that energy-based vessel sealing devices may decrease operating time, blood loss, and hospital stay. There was no difference in complication rate and no studies investigated mortality or quality of life.

SYSTEMATIC REVIEW REGISTRATION: PROSPERO, http://www.crd.york.ac.uk/PROSPERO, check details CRD42011001124. (Obstet Gynecol 2011;118:1127-36) DOI: 10.1097/AOG.0b013e3182324306″
“Underlying molecular

genetic mechanisms of diseases can be deciphered with unbiased strategies using recently developed technologies enabling genome-wide scale investigations. These technologies have been applied in scanning for genetic variations, gene expression profiles, and epigenetic changes for oral and craniofacial diseases. However, these approaches as applied to oral and craniofacial conditions are in the initial stages, and challenges remain to be overcome, including analysis of high throughput data and their interpretation. Here, we review methodology and studies using genome-wide approaches in oral and craniofacial diseases and suggest future directions. Oral Diseases (2013) 19, 111-120″
“This study compared the effects of external hex, internal octagon, and internal Morse taper implant-abutment connections on the peri-implant bone level before and after the occlusal loading of dental implants.