OBJECTIVE: To reassess the association between HDL-C and its subtractions with coronary artery disease (CAD) in childhood-onset type 1 diabetes.

METHODS: Epidemiology of Diabetes Complications study participants free of CAD at baseline (301 men, 298 women; mean age, 27.1 and diabetes duration, 18.9 years) were studied. CAD was defined as angina, ischemic

electrocardiogram changes, confirmed myocardial infarction, angiographic stenosis >= 50%, revascularization, or CAD death. Cholesterol in the HDL fraction and HDL3 cholesterol subfraction was measured enzymatically after precipitation with heparin/manganese and dextran sulfate, respectively.

RESULTS: During 18 years of follow-up, 29.5% of men and 25.5% of women developed CAD. Although a linear decrease in incidence was observed with increasing HDL-C concentration in men, incidence NVP-AUY922 datasheet increased in women at less than 47 mg/dL and greater than 80 mg/dL. These patterns largely reflected the HDL3 cholesterol-CAD association. After multivariable adjustment, the linear, inverse, HDL-C/CAD association

persisted in men (hazard ratio [HR] 0.97, 95% confidence interval [CI] 0.94-0.99); in women, click here the U-shaped relationship lost significance. HDL3 cholesterol remained multivariably associated with CAD in both men (linear association, P = .03) and women (HR 2.31 (95% CI 1.31-4.08) and HR 1.80 (95% CI 1.01-3.23) for the lowest and highest versus the middle quintiles, respectively).

CONCLUSION: The increased CAD risk in women for an HDL-C >80 mg/dL in type 1 diabetes merits further study. Gender specificity could not be determined as only two men had HDL-C >80 mg/dL. (C) 2011 National Lipid Association. All rights reserved.”
“We report the case of a 39-year-old male patient who experienced

central serous chorioretinopathy after surgical repair of a blowout fracture. This patient developed 查看更多 bilateral central serous chorioretinopathy 1 week after surgical reconstruction of left medial and inferior orbital bone fractures. Fundus examination including fluorescein angiography and optical coherence tomography was performed. Central serous chorioretinopathy was more severe in the operated eye. Fortunately, the macular edema subsided, and the patient’s vision normalized after 2 months without treatment.”
“Due to the enormous potential and impact that stem cells may have on regenerative medicine, there has been a rapidly growing interest for tools to analyze and characterize the behaviors of these cells in vitro in an automated and high throughput fashion. Among these behaviors, mitosis, or cell division, is important since stem cells proliferate and renew themselves through mitosis. However, current automated systems for measuring cell proliferation often require destructive or sacrificial methods of cell manipulation such as cell lysis or in vitro staining.