Odds ratios (OR) and 95% confidence intervals were also calculate

Odds ratios (OR) and 95% confidence intervals were also calculated.

Results

Data from this study show that subjects heterozygous and homozygous for the most

frequent allele of the osteopontin gene at position 89261521 [OR: 0.035 (P=0.035*) (allele A)] and 89253600 [OR: 0.20 (P=0.025*) (allele T)], respectively, are protected against postorthodontic EARR. Nevertheless, a highly significant association was found Selleck C59 in the comparative analysis of homozygous subjects [2/2 (CC)] for the osteopontin gene (rs9138), resulting in an increased risk of suffering postorthodontic EARR[OR: 4.10; P=0.045*;CI: 95%]. Subjects who were homozygous [2/2 (CC)] for the osteopontin gene (rs11730582) were more likely, and to a greater extent, to be affected with EARR [OR: 11.68; PCI: 95%] compared with other genotypes.

Conclusion

Variations in the osteopontin gene

(rs9138 and rs11730582) are determinants of a genetic predisposition to suffer EARR secondary to orthodontic treatment.”
“Objective: To assess the effectiveness and safety of sodium selenite in treatment of patients with Kashin-Beck disease (KBD).

Methods: We searched for all publications between January 1966 and October 2011 using seven electronic databases. All randomized controlled trials (RCTs) assessing the effects of sodium selenite on KBD vs no treatment or placebo were included. For dichotomous data, odds ratios (OR) and 95% confidence intervals (Cl) Smoothened Agonist Stem Cells & Wnt inhibitor were estimated according to the intention-to-treat principles. For continuous data, mean difference (MD) was used for outcomes pooled on the same scale.

Results: A total of 10 RCTs involving 2244 patients were included. The methodological quality of the included studies was low. When comparing the outcome of sodium selenite treatment group vs the control group, the OR of repairing rate of metaphyseal lesions was 5.63 (95% CI: 3.67-8.63) and repairing rate at the distal end of

phalanges was 2.98 Staurosporine mouse (95% CI: 1.32-6.70) based on X-ray assessment, which was statistically significant difference in favour of sodium selenite. In one RCT which reported data on clinical improvement, no statistically significant difference was observed in the treatment vs control group (OR 1.50, 95% CI: 0.43-5.30). Se content in hair was (MD 0.11, 95% CI: 0.09-0.13) which was statistically significant higher in selenium group.

Conclusions: Current evidence suggests that sodium selenite is more effective than placebo or no treatment in patients with KBD. However, the evidence was limited by potential biases; thus, further high quality large-scale RCTs are still needed to evaluate the short term and long term effects of selenium. (C) 2012 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

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