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“Recurrent urinary tract infections (UTI) are very common in otherwise healthy young women, and can have a very negative social and economic impact. In order to evaluate the tolerability and efficacy of a 14-day course of prulifloxacin orally administered once daily, 51 young female patients, attending the same STD center between May and June 2007 for symptoms of Selleckchem 4EGI-1 cystitis, with a history of recurrent UTI and urine culture positive for uropathogens, were enrolled

in this prospective study. Microbiological and clinical efficacy was tested over three follow-up visits at 1, 3 and 6 months. Quality of life (QoL) was measured and the impact of prulifloxacin in modifying the Lactobacillus vaginal flora was also evaluated. At baseline, the pathogens most commonly isolated were Enterococcus faecalis (43.2%) and Escherichia coli (27.5%). 41 of the 51 women, (80.3%) had Lactobacillus spp. in vaginal samples at baseline. Microbiological results at follow-up examinations were as follows: after 1 month, 47 patients Torin 2 were recurrence-free and 4 had recurrence; after 3 months, 41 were recurrence-free, while 6 reported recurrence; finally, after 6 months, 36 were recurrence-free and 5 had recurrence. A statistically significant difference was reported between the QoL questionnaire mean scores at baseline (0.63),

1 (0.77), 3 (0.77) and 6 months (0.78) after treatment (all p<0.001). The vaginal swab cultures demonstrated that Lactobacillus spp. flora was maintained in 38 out of the 41 (92.6%) patients who had positive

vaginal swab sample at baseline. In conclusion, a 14-day administration of prulifloxacin 600 mg is a safe, well tolerated and effective treatment Selleck PFTα for the management of UTI in young women.”
“We demonstrate spin-torque induced coherent auto-oscillation in magnetic tunnel junctions of composition PtMn/CoFe/Ru/CoFeB/MgO/CoFeB and of low resistance-area product. At the generation threshold, we observe a strong line narrowing down to 6 MHz at 300 K and a dramatic increase in oscillator power, yielding spectrally pure oscillations with extremely low flicker noise. The induced auto-oscillations are observed even at zero applied field. The frequency of the oscillation mode, and its dependence with easy and hard axis fields are consistent with an acoustical excitation of the two layers of the synthetic ferrimagnet subsystem. Setting the synthetic ferrimagnet into auto-oscillation requires the current polarity that transfers electrons from the synthetic ferrimagnet to the free layer. In auto-oscillation mode, line jitter is observed such that it is the line envelope that is measured in most cases. The line properties for applied fields near the instability boundaries of the Stoner astroid of the free layer indicate that the phase coherence of the auto-oscillation is likely to be affected by the free layer magnetic noise. (C) 2009 American Institute of Physics.