” The current study provides evidence that a diagnosis of VTE is common among nursing home residents across all observed age and gender categories. VTE may be encountered as an existing condition noted on admission, likely originating

Ceritinib nmr outside of the nursing home, and separately, as an acute condition that originates in the nursing home setting. Regarding the latter group, a recent report evaluated a subset of residents who developed VTE during nursing home residence, obtained from the same database used in the current study.21 Two-thirds of these residents received warfarin within 45 days of the VTE incident event. Patients who were underweight, had Alzheimer disease/dementia or cancer, or had independent physical functioning were less likely to receive warfarin. Nonpersistence of warfarin therapy was strongly related to antipsychotic use, presence of dementia, and peripheral vascular disease. In our study, approximately 1 in 25 initial nursing home admissions had

a contemporaneous MDS assessment listing VTE as a current diagnosis. This is a substantial finding given the serious nature of this disease, the potentially short hospital stays before nursing home entry, and concerns about continuity of Epigenetics Compound Library cell assay care after hospital discharge. Little is known from published research regarding how VTE is managed in the nursing home. The VTE event would likely have originated in the hospital before nursing home transfer. On admission to the nursing home, a number of concerns are presented to clinical staff. Because of the lingering potential for sudden death either directly from existing PE or through the progression of DVT to PE, these residents would require adequate assessment to review, modify, and monitor hospital-initiated therapy. Because current consensus guidelines recommend at least 3 months of anticoagulant therapy from the start of VTE,2 and 22 treatment would be expected to commence in the hospital setting and then continue after nursing home admission. One concern is whether warfarin is ever initiated on admission after bridging from short-term low-molecular-weight heparin

or unfractionated heparin. For instance, Caprini et al23 found that only 51% of patients having VTE in the hospital were discharged with a warfarin prescription, having an average Org 27569 hospital LOS of only 7.9 days. Even after considering age, evidence suggests that VTE occurs at a far higher rate among nursing home residents than among community dwellers. In our study, the incidence rate of 3.68 VTE cases per 100 PY occurred among residents with a median age of 78 years. White et al24 reported communitywide incidence rates of new VTE cases of only 0.45–0.60 per 100 PY among individuals aged ≥80 years. White et al24 also found that early mortality after VTE is strongly associated with presentation of PE, advanced age, cancer, and underlying cardiovascular disease.