The obsessions interfere with attention and concentration, thus interfering with cognitive tasks and often social interactions. The obsessions and compulsions can be very

time-consuming: they interfere with functioning because of the time they occupy, and because patients with OCD often develop patterns of avoidance of situations or things that provoke their obsessions or compulsions. OCD typically begins in late adolescence or early adulthood with an earlier age of onset for males than females.8-10 In adult clinical samples, OCD is equally common in females as in males,“ but, due to a higher incidence of childhood-onset OCD in males, younger samples have more males than females.12 Compared with clinical samples, epidemiological #JNK inhibitor mw keyword# studies tend to show a later age of onset and a higher proportion of females than males.12 The lifetime prevalence of OCD is estimated to be between 1.9% and 3.3%. 12 Most studies show a chronic course that extends across the lifetime with waxing and waning of symptoms, although in about 10% of cases

there is a malignant deteriorating Inhibitors,research,lifescience,medical course.9,13 Neurobiological evidence shows clearly that the serotonin system is important in OCD. This evidence has come from treatment response to serotonin reuptake inhibitors (SRIs), including studies of SRIs versus desipramine, which demonstrated the selective efficacy of SRIs,14,15 as well as from pharmacological challenge studies and cerebrospinal fluid Inhibitors,research,lifescience,medical neurotransmitter metabolite studies.16 There is also evidence, Inhibitors,research,lifescience,medical however, of a role for the dopamine system in OCD on the basis of both theory (derived from basic human and animal research) and the efficacy of dopaminergic augmentation in refractory OCD.16,17 Neuroimaging in OCD has revealed much about the disorder and about the effects of treatment. Structural imaging supports the hypothesis that the OC spectrum disorders involve corticostriatal dysfunction6; specifically, magnetic resonance imaging (MRI) studies have shown volumetric abnormalities in the caudate and Inhibitors,research,lifescience,medical a rightward shift in caudate volume. Functional imaging in OCD has shown increased activity in the corticostriatal pathway involving the orbitofrontal

cortex and the caudate nucleus.6,18 Importantly, successful treatment of OCD with cither SRI or cognitive behavioral therapy (CBT) results in normalization of orbitofrontal activity.6,19,20 There are now a number of pharmacotherapies available Urease for treating OCD. The first medication discovered to be effective in OCD was clomipramine, a serotonin and norepinephrine reuptake inhibitor (SNRI).21 The development of selective serotonin reuptake inhibitors (SSRIs) greatly expanded the options for treatment of OCD. The SSRIs have more favorable side-effect profiles than clomipramine, and have become the first-line treatments for OCD. They include citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline. Venlafaxine, a newer SNRI, is also used to treat OCD.