The range of brain pathology was limited to acute, severe congestion, white matter edema, and neuronal karyorrhexis (pontosubicular

necrosis with or without neuronal karyorrhexis at other sites). Established periventricular leukomalacia was present in only 2 cases. The presence of neuronal karyorrhexis or white matter gliosis was correlated with the presence of a high-grade inflammatory lesion and with fetal thymic involution. Neuronal karyorrhexis, but not white matter gliosis, correlated as well with histologically established fetal vascular lesions in the placenta, even once the effect selleckchem of inflammation was accounted for. Gliosis also correlated with inflammation, meconium staining, and thymic involution. Central nervous system injury may be the end result of complex placental pathologies, and neuronal injury may be

https://www.selleckchem.com/products/Y-27632.html a consequence of the fetal inflammatory response. The correspondence between the time courses of histological features of chorioamnionitis, neuronal karyorrhexis, and thymic involution points to irreversible central nervous system injury being common 12-48 hours prior to in utero demise.”
“We show that the misfit strain due to the film-substrate lattice mismatch strongly increases the value of the quadratic magnetoelectric coupling. The coupling, size effects, and misfit strains cause strong changes in the phase diagrams of ferroic films at zero external magnetic and electric fields. The antiferromagnetic to ferromagnetic or ferrimagnetic phase transitions for compressive or tensile misfit strains open the way for the tailoring of magnetic and electric properties of ferroic films leading to advanced

applications.”
“A smooth flagellum moves in the opposite direction of the propagation of flagellar waves. Conversely, a flagellum covered with appendages perpendicular to the main flagellum, called mastigonemes, moves in the same direction as the propagation of flagellar waves. Inspired by mastigoneme structures in nature, we report the reversal of the swimming direction of magnetically actuated artificial helical microswimmers. The main flagella and mastigonemes of these microswimmers are fabricated together using three-dimensional lithography and electron beam evaporation of ferromagnetic thin films. The results show that the swimming speed and CX-6258 molecular weight direction can be controlled by changing the length/spacing ratio of the mastigonemes. (C) 2013 AIP Publishing LLC.”
“Malignant rhabdoid tumor is a highly aggressive pediatric neoplasm molecularly characterized by inactivating mutations of the SMARCB1 gene, a potent tumor suppressor and member of the SWI/SNF chromatin remodeling complex. It has been suggested that oncogenesis in SMARCB1-deficient cancers, such as malignant rhabdoid tumors, is driven not by the loss of SWI/SNF function but by an aberrant functioning of the BRG1-containing SWI/SNF complex.