Therefore, we studied physical activity levels, in Dutch children

Therefore, we studied physical activity levels, in Dutch children and adolescents with haemophilia as well as its association with aerobic fitness and joint health. Forty-seven boys with haemophilia (aged 8–18) participated. Physical activity was measured using the Modifiable Activity Questionnaire (MAQ) and was compared check details with the general population. Aerobic fitness was determined using peak oxygen uptake (VO2peak). Joint health was measured using the Haemophilia Joint Health Score (HJHS). Associations between physical activity, joint health and aerobic fitness were evaluated by correlation analysis. Subjects were 12.5 (SD 2.9) years old, had a Body Mass Index (BMI)

of 19.5 (SD 3.1; z-score 0.5) and a median HJHS score of 0 (range 0–6). Cycling, physical education and swimming were most frequently reported (86%, 69% and 50% respectively). Children with severe

haemophilia participated significantly less in competitive soccer and more in swimming than children with non-severe haemophilia. Physical activity levels were similar across haemophilia severities and comparable find more to the general population. VO2peak kg−1 was slightly lower than healthy boys (42.9 ± 8.6 vs. 46.9 ± 1.9 mL kg−1 min−1; P = 0.03). Joint health, aerobic fitness and physical activity showed no correlation. Dutch children with haemophilia engaged in a wide range of activities of different intensities and showed comparable levels of physical activity to the general population.

Aerobic fitness was well preserved and showed no associations with physical activity levels or joint health. “
“This chapter contains sections titled: Introduction About factor VIII and IX Laboratory work-up for the diagnosis of hemophilia Factor IX: C measurements Models for studying the entire process of coagulation Determination of the antigens of factor VIII and factor IX Inhibitors to factor VIII and factor IX Conclusion References “
“Summary.  Multi-site studies MCE are necessary in the field of haemophilia to ensure adequate sample sizes. Quality of life (QoL) instruments need to be harmonized across languages and cultures to facilitate their inclusion. The purpose of this study was to adapt the Canadian Haemophilia Outcomes – Kids Life Assessment Tool (CHO-KLAT©) and HAEMO-QoL-A© to French for Canada. The CHO-KLAT and the HAEMO-QoL-A are haemophilia-specific measures of QoL for boys and men respectively. Both measures originated in English, were translated into Canadian French by clinicians with expertise in haemophilia care, back-translated by expert translators and harmonized by a multi-disciplinary team. The harmonized versions were evaluated through a cognitive debriefing process with 6 boys with haemophilia, their parents and 10 men with haemophilia.

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