To obtain a higher degree, several members of the dynasty, like Ephraim, studied in Bordeaux—and did so with distinction—but in Ephraim’s case this was only late in life, namely at the age of 43 (according to the Hebrew calendar).The

reason for this delayed graduation is not clear. It is likely that he practiced as a general physician in Amsterdam but needed the doctorate for a higher position. The Bordeaux University Archives describe in detail the ceremony where Ephraim was awarded his doctorate. The three examiners were all descendants of converted Jews, so-called Marranos, whose families had lived in southern France for generations. The patron of the thesis, Professor Lopes (an old friend of Ephraim’s father), www.selleckchem.com/products/AP24534.html accorded him the title of “Magnus Inhibitors,research,lifescience,medical in Medicina.” From there, Ephraim joined the some 400 Portuguese Inhibitors,research,lifescience,medical Jews in Amsterdam. Apart from practicing medicine, he was also a scholar of the Bible. Indeed, together with Ben Manasseh and Jonah Abravanel, Ephraim published poetry,

translated into Spanish the Psalms of David, and in 1650 published Pene Rabbah, an index to the biblical passages found in the Midrash Rabbah. He also founded the charitable organization “Torah Or” in Amsterdam. He must have been appreciated as a physician as he attended, together with his father Joseph, the Regent of the Netherlands, the Prince of Orange. Rembrandt depicted his physician Ephraim on two occasions. It is not known if Inhibitors,research,lifescience,medical Inhibitors,research,lifescience,medical these portraits were commissioned; possibly they were honoraria for medical services provided by Dr Bueno. There is firstly an etching of 1647, Dr Bueno Descending the Stairs, where he is shown in well-to-do attire

with the obvious ring on his index finger representing the insignia of the medical community (Figure 1).1 Prints of this etching are found today in museums around the world, such as the Metropolitan Museum in New York and the National Gallery of Victoria in Melbourne, Australia, etc. Figure 1. Rembrandt’s Inhibitors,research,lifescience,medical etching of Dr Ephraim Bueno, 1647 (in public domain). Rembrandt’s second image of his private physician was an oil portrait, today in the Rijksmuseum, Amsterdam.9 This oil painting has an interesting provenance: originally it was in the possession of the Six family and remained so for over two centuries. Then, in the early twentieth century, it was bought by the Jewish banker Fritz Mannheimer. The image of this Jewish physician was then purchased on behalf of Hitler’s intended “Fuehrer Museum” in Linz, Austria (which never eventuated), Dacomitinib and it was transferred to the Central Collection Point in Munich in 1942. After the fall of the Third Reich the painting was returned to the Netherlands in 1948 and was finally transferred to the Amsterdam Rijksmuseum in 1960. In 1656 Ephraim, as an old man, was also etched by another selleck chem inhibitor famous artist, Jan Lievens (Figure 2). The figure is seated, wearing a Kippah, and at the bottom of the print is written: “Dr Ephraim Bonus, Medicus Hebraeus … Magnus in Medicis.