In this study, we found that circulating B-lymphocytes, produ

\n\nIn this study, we found that circulating B-lymphocytes, producing autoantibodies to endothelial cells, played an important role in the pathogenesis of TA. It means that part/all of the circulating B-lymphocytes in TA patients can Selleckchem Sonidegib be activated and excrete autoantibodies to endothelial cells. If these abnormal circulating B-lymphocytes can be differentiated and separated from peripheral blood, the active phase could be shorten, the inactive

stage could be lengthened, the disease could even be prevented. It might lessen the autoimmune injury of artery wall, lower the difficulty of the operation and shorten the time which TA patients should wait for vascular reconstructive operations or endovascular repair. Therefore, we regarded this study as a foundation of B-cell depletion therapy and/or immunological tolerance therapy for

TA. The feasible therapeutic methods will be explored in our future research.”
“Embryonic stem cells are considered to be a good in vitro tool to study the induction of various LCL161 chemical structure cell types including cardiomyocytes; however, induction of the pharyngeal endoderm (PE), the underlying heart-forming region, in vivo has been scarcely reported. In the present study, we found that many PE-related genes, such as Pax1, Pax9, Six1, and Tbx1, were up-regulated in cardiomyocyte-rich embryoid bodies (EBs). The third pouch-related genes including Hoxa3, Foxn1, and Aire, which are crucial for thymus development and function,

were also detected in later stages. Nkx2.5, a cardiac transcription factor gene, is known to be transiently expressed in the PE. By crossing Nkx2.5-Cre mice with Cre-dependent EGFP reporter mice, we found Buparlisib that Nkx2.5(+) lineage exclusively contributed to thymic epithelial cell development, followed by thymus development. Gene expression analysis using Nkx2.5-EGFP ES cells also revealed that PE-related mRNAs were specifically enriched in the transiently appearing E-cadherin(+)Nkx2.5(+) cell fraction. Interestingly, the EB-derived cells were found capable of supporting T-cell differentiation to CD4 or CD8 double-positive cells in a reaggregation organ culture in vitro. Our results suggest that EBs contain cells that resemble third pharyngeal pouch endoderm and confer a thymus-like microenvironment.”
“Gastric cancer, the most common cancer in Korea, has come to be more frequently detected in the early stage thanks to regular endoscopy regardless of gastrointestinal symptoms. Early gastric cancer can be treated by endoscopic submucosal dissection or laparoscopic surgery, and its prognosis is very excellent. Thus, it is of an utmost importance to develop efficient screening method and set appropriate interval for the accurate diagnosis of early gastric cancer.

Average radiation dose with CT examinations was 1 mSv Of the pos

Average radiation dose with CT examinations was 1 mSv. Of the postoperative nonsubluxated hips (n = 30 for CT and n = 37 for MRI), CT demonstrated a sensitivity of 100% and a specificity of 96%, whereas MRI exhibited a sensitivity of 100% and a specificity of 100%. Of the postoperative subluxated

hips, 66.7% spontaneously reduced, 22.2% remained subluxated, and 11.1% redislocated.\n\nConclusions: This is the first study to compare these imaging modalities in the evaluation of hip reduction in DDH. This study affirms MRI as an alternative BEZ235 to CT scan. The sensitivity and specificity of both modalities appears excellent. Similar to other studies, a large percentage of subluxated hips in both groups reduce without additional surgical intervention.\n\nLevel of Evidence: Diagnostic level II.”
“Objective: Currently, human chorionic gonadotropin (hCG) follow-up after evacuation of hydatidiform moles is essential

to identify patients requiring chemotherapeutic treatment for gestational trophoblastic neoplasia (GTN). We propose a model based on linear regression of postevacuation serum hCG concentrations for the prediction of GTN. Methods: One hundred thirteen patients with at least 3 buy Fer-1 serum samples from days 7 to 28 after evacuation were selected from the Dutch Central Registry for Hydatidiform Moles (1994-2009). The slopes of the linear regression lines of the first 3 log-transformed serum hCG and free beta-hCG values were calculated. Receiver operating characteristic curves were constructed to calculate areas under curve (AUCs). Results: The slope of the hCG regression line showed an AUC of 0.906 (95% confidence interval, 0.845-0.967). Gestational trophoblastic neoplasia could be predicted in 52% of patients with GTN at 97.5% specificity (cutoff, -0.020). Twenty-one percent of patients with GTN

could be predicted before diagnosis according to the International Federation of Gynecology and Obstetrics 2000 criteria. The slope of free beta-hCG showed an AUC of 0.844 (95% confidence interval, 0.752-0.935), 69% sensitivity at 97.5% specificity, and 38% of patients with GTN could be predicted before diagnosis according to the International Federation of Gynecology and Obstetrics criteria. Conclusions: The slope of the linear regression line of hCG proved to be a good test to discriminate between patients who will achieve spontaneous disease remission and patients Ro-3306 purchase developing GTN. The slope of free beta-hCG seems to be a better predictor for GTN than the slope of hCG. Although this model needs further validation for different assays, it seems a promising way to predict the more aggressive cases of GTN.”
“High accuracy non-relativistic quantum chemical calculations of the ground state energies and wave-functions of symmetric three-particle Coulomb systems of the form m(1)(+/-)m(2)(+/-)m(3)(-/+), m(1) = m(2), are calculated using an efficient and effective series solution method in a triple orthogonal Laguerre basis set.

Results: Prior to the unit, 38% of students self-reported ant

\n\nResults: Prior to the unit, 38% of students self-reported anticipated discomfort with caring for transgender patients. In addition, 5% of students reported this website that the treatment was not a part of conventional medicine. Students in the second-year class were no different than other students. Subsequent to the teaching unit, the second-year students reported a 67% drop in discomfort with

providing transgender care (P<.001), and no second-year students reported the opinion that treatment was not a part of conventional medicine.\n\nConclusion: A simple change in the content of the second-year medical school curriculum significantly increased students’ self-reported willingness to care for transgender patients.”
“The hippocampus and adjacent structures in the medial temporal lobe are essential for establishing new associative memories. Despite this knowledge, it is not known whether the hippocampus proper is essential for establishing such memories, nor is it known whether adjacent regions like the entorhinal cortex might contribute. To test the contributions of these regions to the formation selleck compound of new associative memories, we trained rhesus monkeys to rapidly acquire arbitrary visuomotor associations, i.e.,

associations between visual stimuli and spatially directed actions. We then assessed the effects of reversible inactivations of either the hippocampus (Experiment 1) or entorhinal cortex (Experiment 2)

on the within-session rate of learning. For comparison, we also evaluated the effects of the inactivations on performance of problems of the same type that had been well learned prior to any inactivations. We found that LCL161 datasheet inactivation of the entorhinal cortex but not hippocampus produced impairments in acquiring novel arbitrary associations. The impairment did not extend to the familiar, previously established associations. These data indicate that the entorhinal cortex is causally involved in establishing new associations, as opposed to retrieving previously learned associations. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.”
“To study the impact of provenance selection of planting stock in (re)forestation and landscape plantings, the variation in bud and flower phenology, height increment and shrub morphology was examined within and between the local and non-local provenances of Crataegus monogyna in a provenance trial. Seven Belgian provenances were included, five in Flanders and two in Wallonia, completed with three commercial provenances originating from Italy, Hungary and the United Kingdom. A completely randomized design (single tree plots) was adopted. Data were processed using mixed modelling techniques. South European provenances flushed up to 7 days earlier than the Flemish provenances, whereas the Walloon provenances flushed 4 days later.

This article updates the concepts of some of the major categories

This article updates the concepts of some of the major categories of conditions that can potentially suppress the immune response, including HIV disease, to provide a conceptual frame to assess patients with suspected secondary deficiencies of the immune system.”
“Metabolic syndrome is associated with an increased risk of colorectal

cancer. This study investigated the impact of hypertension, a component of metabolic syndrome, on azoxymethane (AOM)-induced colorectal carcinogenesis using SHRSP/Izm (SHRSP) non-diabetic/hypertensive rats and SHRSP.Z-Lepr(fa)/IzmDmcr (SHRSP-ZF) diabetic/hypertensive rats. Male 6-week-old SHRSP, SHRSP-ZF, and control non-diabetic/normotensive Wister Kyoto/Izm (WKY) rats were given

2 weekly intraperitoneal injections of AOM (20 mg/kg body weight). Two weeks after the last injection of AOM, the SHRSP and SHRSP-ZF rats became hypertensive compared to the control WKY rats. Serum levels of angiotensin-II, the active product of the renin-angiotensin system, were elevated in both SHRSP and SHRSP-ZF rats, but only the SHRSP-ZF rats developed insulin resistance, dyslipidemia, and hyperleptinemia and exhibited an increase in adipose tissue. The development of AOM-induced colonic preneoplastic lesions and aberrant crypts foci, was significantly accelerated in both SHRSP and SHRSP-ZF hypertensive rats, compared to WKY normotensive rats. Furthermore, induction of oxidative stress and exacerbation of inflammation were observed in the colonic mucosa Cl-amidine mw and systemically in SHRSP and SHRSP-ZF rats. Our findings suggest that hypertension plays a role in the early stage of colorectal carcinogenesis by inducing oxidative stress and chronic inflammation,

which might be associated with activation of the renin-angiotensin system.”
“Background: The aim of this study was to assess the most relevant echocardiographic GDC-0068 parameter for the clinical diagnosis of acute dyspnea due to left-heart dysfunction.\n\nMethods: Transthoracic echocardiography was performed in 88 patients in sinus rhythm admitted for respiratory distress. Two experts determined the cause of dyspnea as cardiogenic (26 patients) or noncardiogenic (62 patients).\n\nResults: The feasibility was 100% for the E/A ratio and the E/E deceleration time (EDT) ratio but 97%, 89%, and 85% for the E/Ea ratio, left ventricular ejection fraction (LVEF), and the E/propagation velocity (Vp) ratio, respectively. The area under the receiver operating characteristic curve for E/EDT (0.947 +/- 0.035) was statistically significantly greater than that for E/A (0.753 +/- 0.068) (P = .004). The areas under the curves for all other parameters were not statistically significantly different. In the subpopulation of patients with LVEFs > 45%, the area under the curve for LVEF was significantly smaller than those for E/Ea, E/EDT, and E/Vp.

A discussion is presented on distributional habitat records and b

A discussion is presented on distributional habitat records and biogeography.”
“Toll-like receptors (TLRs) and defensins (DEFs) play a crucial role in the host’s innate immunity and may influence HIV-1 OSI-906 disease progression. We investigated the impact of TLR9 + 1174G>A, 1635A>G and DEF beta 1 – 44C>G, -52G>A single nucleotide polymorphisms on the clinical outcome of 95 HIV-1-infected children. The TLR9 1635AG genotype and TLR9 [G;G] haplotype were associated with rapid disease progression, whereas the DEF beta 1 -44CG genotype and DEF beta

1 [G;G] haplotype correlated with a better clinical outcome.”
“The effect of brain extract from females of freshly emerged Tenebrio molitor on ovary, oocyte development, total protein content of hemolymph, and ovary was studies in 4-day-old adult mealworm females. Injections of extracts of 2-brain equivalents into intact (unligatured) Tenebrio females did not affect ovarian

and oocyte development. Injections of ligated females, however, with 2-brain equivalents and day 1 and 2 after adult emergence strongly inhibited ovarian growth and oocyte development. At day 4, ligated and injected females did not develop their ovaries and pre-vitellogenic oocytes were not found. The changes in ovarian development correlated with an increase in the concentration of soluble proteins in the hemolymph as compared with Selleck Birinapant the saline-injected controls. Additionally, a strong reduction of total protein content in ovarian tissue was observed. Reverse phase HPLC separation of a methanolic brain extract of T. molitor females showed that fraction 5 has a similar retention time to synthetic cockroach allatostatin. Fraction 5 was eluted at 12.88 min, which was closest, to the internal standard Dippu-AST 1, which eluted at 12.77 min. An ELISA of fraction 5 from the methanolic brain extract using antibodies against allatostatins Grybi-AST A1 and Grybi-AST B1 from cricket Gryllus bimaculatus showed that fraction 5 cross-reacted with Grybi-AST A1 antibodies. The cross-reactivity was similar to the synthetic allatostatin from D. punctata, which MK-8776 was used as a positive control. These

observations demonstrate a possible role for allatostatin-like brain factor(s) in regulating the reproductive cycle of Tenebrio molitor (C) 2009 Wiley Periodicals, Inc.”
“Objective: To search for CDKL5 gene mutations in boys presenting with severe early-onset encephalopathy and intractable epilepsy, a clinical picture very similar to that already described in girls with CDKL5 mutations.\n\nMethods: Eight boys (age range 3-16 years, mean age 8.5 years, SD 4.38) with severe or profound mental retardation and early-onset intractable seizures were selected for CDKL5 gene mutation screening by denaturing high-performance liquid chromatography analysis.\n\nResults: We found three unrelated boys carrying three different missense mutations of the CDKL5 gene: c. 872G > A ( p. C291Y), c.

The resultant tumor does not grow from the stomach’s

The resultant tumor does not grow from the stomach’s ACY-1215 manufacturer mucosal surface, so it does not mimic the human disease process.\n\nSTUDY DESIGN: A

low-dose gastric mucosal coagulation was done transorally in the body of stomach using a specially designed polyethylene catheter in 16 female severe combined immunodeficient mice. This was followed by the instillation of SNU-16 human gastric cancer tumor cells (1 x 10(6) cells). Five mice each were euthanized at 1 and 2 months, and 6 mice were euthanized at 3 months. Three control mice underwent electrocoagulation alone and 3 mice underwent cell line instillation alone.\n\nRESULTS: Tumors were detected in 11 of 16 experimental mice, but not in the control mice. Tumors were noted in mice at 1 month. Over time, there was an increase in tumor growth and metastasis CYT387 to lymph nodes and surrounding organs. Histopathologic evaluation showed that the tumors grew from the gastric mucosa.\n\nCONCLUSIONS: Our model is easy to create and overcomes the limitations of the existing models, as the tumor arises from the stomach’s mucosal layer and mimics the human disease in terms of morphology and biologic behavior. This is the first report of a true orthotopic gastric cancer murine model. This model opens new doors

for additional studies that were not possible earlier. (C) 2013 by the American College of Surgeons)”
“Nonpsychotic anomalies of subjective experience were emphasized in both classic literature and phenomenological psychiatry as essential clinical features of Copanlisib solubility dmso schizophrenia. However, only in recent years, their topicality with respect to the construct validity of the concept of the schizophrenia spectrum has been explicitly acknowledged, mainly as a consequence of the increasing focus on early detection and prevention of psychosis. The current study tested the hypothesis of a specific aggregation of self-disorders (SDs, various

anomalies of self-awareness) in schizophrenia-spectrum conditions, comparing different diagnostic groups; 305 subjects, previously assessed in the Copenhagen Schizophrenia Linkage Study, were grouped into 4 experimental samples, according to their Diagnostic and Statistical Manual of Mental Disorders (Third Edition Revised) main diagnosis: schizophrenia, (n = 29), schizotypal personality disorder (n = 61), other mental illness not belonging to the schizophrenia spectrum (n = 112), and no mental illness (n = 103). The effect of diagnostic grouping on the level of SDs was explored via general linear model and logistic regression. The diagnosis of schizophrenia and schizotypy predicted higher levels of SDs, and SDs scores were significantly different between spectrum and nonspectrum samples; the likelihood of experiencing SDs increased as well with the diagnostic severity.

While the majority of patients with strabismus are treated with s

While the majority of patients with strabismus are treated with surgery there are a number of cases where surgery is not possible and good long-term ocular alignment can be maintained with repeated injections of botulinum toxin.\n\nMethods 65 patients who had undergone over 25 injections of botulinum toxin A for long-term control of their deviation were identified

and asked to fill in and return the Adult Strabismus questionnaire (AS-20) to assess their QoL.\n\nResults 46 questionnaires were available for analysis. The mean AS-20 score in our patients compared favourably with MI-503 research buy that reported for normal controls and was much higher than that reported for patients with strabismus.\n\nConclusion Long-term S3I-201 mw injections with botulinum toxin A is a good treatment for maintaining ocular alignment if squint surgery is not indicated and those patients receiving treatment score near the level of normal controls in QoL terms.”
“Mint protein family, as adaptor molecules, contains three members, Mint1, Mint2 and Mint3. Although Mint3

is ubiquitously expressed, Mint1 and Mint2 have been reported to express specifically in neuron. Here we demonstrated Mint1 and Mint2 expression pattern in rat spinal cord. The protein level of Mint2 was found to be higher than that of Mint1 in rat spinal by western blot. In an attempt to know Mint2 distribution in the spinal cord of rat, in situ hybridization was carried out, Mint2 mRNA was showed to be ubiquitously distributed in cervical, thoracic and lumbar sections of rat spinal cord, and high intensive signal was detected in motor neurons. These were further confirmed by fluorescent immunohistochemistry, Mint2 was also found to exist throughout gray matter especially motor neurons where Mint2 was mainly located in perikaryon, however, Mint1 was showed to be relatively lower. By electron microscope, Mint2 was found to be mainly located in vesicles in perikaryon in motor neuron of lumbar section, and at the same time Mint2 was located in axons in myelin and presynaptic A-1210477 mw terminals. These data suggest that Mint2 may play more

important role in spinal cord than the other two family members.”
“Adaptive adjustments of strategies help optimize behavior in a dynamic and uncertain world. Previous studies in the countermanding (or stop-signal) paradigm have detailed how reaction times (RTs) change with trial sequence, demonstrating adaptive control of movement generation. Comparatively little is known about the adaptive control of movement cancellation in the countermanding task, mainly because movement cancellation implies the absence of an outcome and estimates of movement cancellation require hundreds of trials. Here, we exploit a within-trial proxy of movement cancellation based on recordings of neck muscle activity while human subjects attempted to cancel large eye-head gaze shifts.

The formation of osteoclast-like cells (defined as multinucleated

The formation of osteoclast-like cells (defined as multinucleated, tartrate-resistant

acid phosphatase-positive cells) was assessed at 7 and 14 days. In the presence of M-CSF and RANKL, with and without IL-6, more osteoclasts were formed from TR- PBMCs than from TR+ PBMCs on plastic. More osteoclasts were formed from TR+ PBMCs on bone slices in the presence of M-CSF/RANKL with 1,25(OH)(2)D. This opposite effect may be due to a higher expression of the vitamin D receptor (VDR) in TR+ osteoclasts and precursors on bone. Formation of resorption pits was analyzed and confirmed with scanning electron microscopy. In conclusion, we propose that TR+ PBMCs when cultured on bone are sensitive to 1,25(OH)(2)D, Blebbistatin solubility dmso whereas the differentiation of TR- PMBCs on bone seem more sensitive to IL-6, suggesting that osteoclast precursors from cats with and without tooth resorption respond differently to osteoclast stimulating factors. (C) 2011 Elsevier Ltd. All rights reserved.”
“Conventional and molecular chromosomal analyses were carried out on three populations of Apareiodon ibitiensis sampled from the hydrographic buy AR-13324 basins of the Sao Francisco River and Upper Parana River (Brazil). The results reveal a conserved diploid number (2n = 54 chromosomes), a karyotype formula consisting of 50 m-sm + 4st and a ZZ/ZW sex chromosome

system that has not been previously identified for the species. C-banding analysis with propidium iodide staining revealed centromeric and terminal bands located in the chromosomes of the specimens from the three populations and allowed the identification of heteromorphism of heterochromatin regions in the Z and W chromosomes. The number of 18S sites located through fluorescent in situ hybridization (FISH) varied between the populations of the Sao Francisco and Upper Parana Rivers. The location of 5S rDNA sites proved comparable in one pair of metacentric chromosomes. Thus, the present study proposes a ZZ/ZW sex

chromosome system for A. ibitiensis among the Parodontidae, and a hypothesis is presented regarding possible W chromosome differentiation stages in this species through DNA accumulation, showing geographical variations for this characteristic, possibly SB273005 in vivo as a consequence of geographical reproductive isolation. (C) 2009 The Authors Journal compilation (C) 2009 The Fisheries Society of the British Isles”
“Objective: The study investigates whether preintervention depressive symptoms predict weight loss and whether an increase in depressive symptoms during a group-based lifestyle intervention of 1 year’s duration is associated with failure in weight reduction while controlling for the influence of psychosocial risks. Method: Participants were 136 overweight and obese children and adolescents between 7 and 15 years, who had been referred for weight reduction treatment by local pediatric practices.

The results suggest that healthy individuals with low ERA benefit

The results suggest that healthy individuals with low ERA benefit from intranasal oxytocin application. Neurobiological mechanisms potentially underlying the link between oxytocin, cortsiol and ERA are discussed against the background of a neuroendocrinological perspective on personality. (C) 2010 Elsevier Ltd. All rights reserved.”
“We describe the case of a pregnant woman diagnosed with breast cancer at 26 weeks’ gestation. The tumor was positive for estrogen and progesterone receptors and negative for overexpression of c-erbB-2 protein. Neoadjuvant FAC (fluorouracil, adriamycin, cytoxan) chemotherapy was started at 29 weeks’ gestation. At

37 weeks, delivery was induced and the patient gave born to a healthy female baby weighing 2350 g, after which she was given a further cycle of chemotherapy and weekly paclitaxel. Clinical and radiological remission was achieved. Resection of the breast tissue showed complete

pathological response and negative lymph nodes. This case illustrates how the integrated work of different specialists can obtain excellent oncological and obstetrical results in the care of pregnant women with breast cancer. Free full text available at”
“Background: Runt-related transcription factor 3 (RUNX3) is known as a tumor suppressor gene for gastric cancer and other cancers, this gene may be involved in the development of hepatocellular carcinoma (HCC).\n\nMethods: RUNX3 expression was analyzed by immunoblot and immunohistochemistry in HCC cells and tissues, respectively. Hep3B cells, lacking endogenous RUNX3, were introduced with RUNX3 constructs. Cell proliferation was measured using the MTT assay and apoptosis was evaluated using

DAPI staining. Apoptosis signaling was assessed by immunoblot analysis.\n\nResults: RUNX3 protein expression was frequently inactivated in the HCC cell lines (91%) and tissues (90%). RUNX3 expression inhibited 90 +/- 8% of cell growth at 72 h in serum starved Hep3B cells. Forty-eight hour serum starvation-induced apoptosis and the percentage see more of apoptotic cells reached 31 +/- 4% and 4 +/- 1% in RUNX3-expressing Hep3B and control cells, respectively. Apoptotic activity was increased by Bim expression and caspase-3 and caspase-9 activation.\n\nConclusion: RUNX3 expression enhanced serum starvation-induced apoptosis in HCC cell lines. RUNX3 is deleted or weakly expressed in HCC, which leads to tumorigenesis by escaping apoptosis.”
“Recently, Pokorny and Zhou proved that if parallel to u(3)parallel to(L infinity (0,T;L) (10/3) ((R3))) << 1 or parallel to del u(3)parallel to(L infinity(0,T;L) (30/19) ((R3))) << 1, then the weak solution u of the 3D Navier-Stokes equations is regular on R-3 x (0, T]. In this paper we remove the smallness assumptions by using a new approach which may be of independent interest and further application. (C) 2013 Elsevier Ltd. All rights reserved.

In promptly reversed transient ischemia as after mechanical vascu

In promptly reversed transient ischemia as after mechanical vascular occlusion, primary core injury may recover but a secondary delayed injury evolves after a free interval of as long as 6 to 12 hours. This injury can be alleviated throughout

the free interval but the longer window is without clinical relevance because transient mechanical vascular occlusion is not a model of naturally occurring stroke. As this difference is widely ignored in stroke research, most clinical trials have been designed with a far too long therapeutic window, which explains their failure. Transient mechanical vascular occlusion models should, therefore, be eliminated from the repertoire AZD0530 of preclinical stroke research. Journal of Cerebral Blood Flow & Metabolism (2012) 32, 1310-1316; doi: 10.1038/jcbfm.2011.186; published online 11 January 2012″
“Both systemic lupus erythematosus

(SLE) and its treatment can cause immunosuppression and a decreased response to vaccination. We evaluated 30 children and adolescents with SLE, and 14 age-matched healthy subjects (control group) regarding immunophenotyping and lymphocyte Stattic inhibitor apoptosis by flow cytometry, while measles and tetanus antibodies were measured by enzyme-linked immunosorbent assay (ELISA). The SLE group was divided according to disease activity into inactive SLE and active SLE. Individuals with active SLE had lower CD4+ T and natural killer (NK) cells/mm(3) than the control group. Active and inactive SLE individuals had more CD38 molecules/CD8+ T cells Napabucasin mw and more CD4+ T, CD8+ T and B cells in apoptosis

(as assessed by caspase-3 expression) than the control group. Patients with active SLE had a diminished CD28 expression on both CD4+ T and on CD8+ T cells and a higher CD86 expression on B cells than the control group. Measles antibody levels in the SLE groups were similar to the control group. In contrast, tetanus antibody levels were lower in the SLE groups than in the control group. The latter also directly correlated with the CD4+ T-cell and NK-cell counts from SLE patients (regression coefficient, 2.686 and 1.782; p = 0.010 and p = 0.039, respectively). We concluded that despite being up-to-date for tetanus vaccine, SLE patients presented with a poor immune response to tetanus vaccine. Lupus (2011) 20, 736-744.”
“The aim of this study was to detect different alleles of the prolactin receptor (PRLR) gene and to examine their effects on the litter size of the indigenous Hungarian pig, the Mangalica. G1789A single nucleotide polymorphism (SNP) was investigated as a candidate for litter size. Samples from 80 purebred Mangalica sows and data of their 335 litters were provided by Olmos & Toth Ltd. Hair follicles were used to isolate the required DNA.